VasCog 2023

Program
What's on

PRE – CONFERENCE AFTERNOON MASTER CLASSES

September 13th 13:00 – 18:00

Co-Chairs: Anna Marseglia and Hilde van den Brink

Conference room RunAn – Snack and drinks will be delivered at 17.00

Master class 1: VCI - Diagnosis and neuropathological features

Eric Smith, Raj Kalaria

Master class 2: Biomarkers in VCI

Marco Duering – Neuroimaging, Donna Wilcock – Fluid biomarkers from MarkVCID, Carol Cheung – Retinal biomarkers

Master class 3: Future challenges in VCI

Geert Jan Biessels

ECI Mixer

MAIN CONFERENCE

08:30 - 08:40

Opening ceremony – Ingmar Skoog, LOC Chair

THEME 1: WHATS GOING ON? NEW PERSPECTIVES IN VCI – Chairs: Ingmar Skoog & Anna Marseglia

08:40 - 08:50

Invited talk: Sex differences in VCI: from biomarkers to treatment: Lieza Exalto (F), Dept Neurology, UMC Utrecht, the Netherlands

08:50 - 09:00

Invited talk: Resilience pathways in VCI: present challenges and future directions: Prashanti Vemuri (F), Mayo Clinic, USA

09:00 - 09:10

Invited talk: Implementing artificial intelligence methods in VCI: what for? Eric Westman (M), Centre for Alzheimer Research; Department of Neurobiology, Care Sciences, and Society; Karolinska Institutet, Stockholm, Sweden

09:10 - 09:20

Invited talk: Life-time perspective on vascular cognitive ageing / Life-course and Epidemiology: Deborah Gustafson (F), State University of New York Downstate Health Sciences University and Stony Brook (SUNY DHSU, SBU), USA

09:20 - 09:30

Invited talk: New perspectives in neuropathology: Elisabet Englund (F), Division of Pathology, Department of Clinical Sciences, University of Lund, Lund, Sweden

09:30 - 09:40

Invited talk: Brain large artery disease contributions to neurodegeneration: Jose Gutierrez (M), Columbia University, New York, USA

09:40 - 10:10

Discussion

10:10 - 10:25

3 selected abstracts for oral presentation (5 mins each)

10:25 - 10:45

Coffee

THEME 2: BIOMARKERS OF VASCULAR COGNITIVE IMPAIRMENT Chairs: Saima Hilal and Annemieke ter Telgte

10:45 - 10:55

Invited talk: Advanced diffusion MRI markers of cerebral small vessel disease: Anna Dewenter (F), Institute for Stroke and Dementia Research (ISD) Munich, Germany

10:55 - 11:05

Invited talk: Fluid biomarkers in VCI: Henrik Zetterberg (M), University of Gothenburg, Sweden

11:05 - 11:15

Invited talk: Deep learning for detection of Alzheimer’s disease based on retinal images: Carol Cheung (F), Chinese University of Hong Kong

11:15 - 11:25

Invited talk: Cardiac dysfunction, neuroimaging and cognition: Saima Hilal (F), National University of Singapore

11:25 - 12:00

Discussion

12:00 - 12:15

3 selected abstracts for oral presentation (5 mins each)

12:15 - 12:20

CCCB and announcement session on international consortia later that day

12:30 - 14:30

Lunch, poster viewing and discussion at groups of 6 thematic posters, e.g., clinical symptoms, blood pressure, white matter lesions, and brain imaging methods.

13:15 - 14:15

Mixer of global consortia or groups that address the global challenge of Vascular Cognitive Disorders including;

1) The Vascular Theme in UK DRI (Joanna Wardlaw)

2) Vascular PIA-Alzheimer’s Association  (Fanny Elahi)

3) STROKOG – the current status (Jessica Lo)

4) An international CADASIL consortium (Raj Kalaria)

5) Meta VCI Map (Geert Biessels)

6) FINESSE – an update (Hugh Markus)

7) International Stroke Genetics Consortium (ISGC) – Genetics of VCID (Stephanie Debette)

8) Reaching international consensus – Delphi and other approaches (P Sachdev)

9) Dementias platform UK (DPUK) (Atticus Hainsworth),

10) Diffusion-weighted imaging positive lesion consortium (DIAGNOSE) (Annemieke ter Telgte)

11) International consortium on cerebral microinfarcts (Saima Hilal)

12) MarkVCID Diverse (Charlie DeCarli)

13) Alzheimer’s Association (Maria Carillo)

14) WW FINGERS (Miia Kivipelto)

The goal is to provide a quick overview of global networks and informal discussion; Chairs: Atticus Hainsworth & Joanna Wardlaw．

14:30 - 15:10

One-minute Poster Blitz:

15:10 - 15:30

Discussion: Chairs: Eric Smith & Audrey Low

15:30 - 16:30

Debate 1: Is SVD a clearly defined clinical and pathological entity Chair: Silke Kern

Group 1 (1) Julie Schneider, (2) Christopher Chen

Group 2 (3) Donna WilcocK, (4) Eric Smith

16:30 - 17:30

Time for VasCog Early Career Investigators meeting with snacks:

– first half: ‘speed dating’ networking

– second half: round table discussion on ECI activities 2024-2025

18:00 - 20:00

Reception:  The City of Gothenburg

08:30 - 08:50

2023 updates – Roxana Carare, SOC Chair

08:30 - 08:40

Update on hypertension: Ingmar Skoog (M), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, AGECAP, University of Gothenburg, Sweden

08:40 - 08:50

Update on atrial fibrillation: Lina Rydén (F), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, AGECAP, University of Gothenburg, Sweden

THEME 3: INFLAMMATION AND OTHER MECHANISMS OF VCI Chairs: Fanny Elahi & Jae-Sung Lim

08:50 - 09:00

Invited talk: Failure of clearance of fluids from the brain and pathogenesis of CAA: Roxana Carare (F)

09:00 - 09:10

Invited talk: Inflammasome in cognitive impairment and dementia: Yuek Ling Chai (F)

09:10 - 09:20

Invited talk: Molecular pathogenesis of CARASIL:  Osamu Onodera (M), Niigata University, Japan

09:20 - 09:30

Invited talk: Cerebrovascular and inflamm-ageing link to dementia: Axel Montagne (M), University of Edinburgh, UK

09:30 - 09:40

Invited talk: The brain on fire: inflammation and cerebral small vessel disease: Frank-Erik de Leeuw (M), Radboudumc, Nijmegen, the Netherlands

09:40 - 10:10

Discussion:

10:10 - 10:25

Selected abstracts for oral presentation (5 mins each)

10:25 - 10:55

Coffee

THEME 4: PSYCHIATRIC CONDITIONS AND VCI Chairs: Jiyang Jiang & John O’Brien

10:55 - 11:05

Invited talk: Occurrence and prognostic value of neuropsychiatric symptoms in patients with Vascular Cognitive Impairment: Geert Jan Biessels (M), UMC Utrecht, the Netherlands

11:05 - 11:15

Invited talk: Neuropsychiatric profiles in stroke patients: A STROKOG collaboration study: Ben Lam (M), University of New South Wales, Sydney, Australia

11:15 - 11:25

Invited talk: Whatever happened to vascular depression? 
John O’Brien (M), University of Cambridge, UK

11:25 - 11:35

Invited talk: Are neuropsychiatric symptoms associated with cerebral small vessel disease presence and progression?  Una Clancy (F), University of Edinburgh, UK

11:35 - 12:15

Discussion:

12:15 - 12:30

3 selected abstracts for oral presentation (5 mins each)

12:30 - 14:30

Lunch, poster viewing and 6 thematic posters discussion groups

14:30 - 15:10

One-minute Poster Blitz:

15:10 - 15:30

Discussion: Chairs: Fanny Elahi & Satoshi Saito

15:30 - 16:30

Debate 2: ATN classifications – updating e.g., VATN Chair: Raj Kalaria

Group 1 Kaj Blennow

Group 2 Fanny Elahi

16:30 - 17:30

Business meetings: Executive Committee (Chaired by Gustafson)

18:00 - 20:00

Industry-sponsored symposia

20:00

Vas-Cog Party: Kajskjulen 8, Packhusplatsen 11, 411 13 Göteborg, Sverige

08:40 - 08:50

Invited talk: It’s all in your head: Vascular Dementia and COVID-19: Gregory Bix (M), Tulane School of Medicine, USA

THEME 5: NEW DIAGNOSES AND CLASSIFICATIONS  Chairs: Hugh Markus & Hilde van den Brink

08:50 - 09:00

Invited talk: The Boston 2.0 criteria: TBA

09:00 - 09:10

Invited talk: STRIVE-2 criteria: Joanna Wardlaw (F), Edinburgh, UK

09:10 - 09:20

Invited talk: Cognitive diagnostic criteria: Perminder Sachdev (M), University of New South Wales, Sydney, Australia

09:20 - 09:30

Invited talk: ARIA-E and ARIA-H: Sandra Black (F), University of Toronto, Canada

09:30 - 10:15

Discussion:

10:15 - 10:30

3 selected abstracts for oral presentation (5 mins each)

10:30 - 11:00

Coffee

THEME 6: WHATS NEW IN TREATMENT AND PREVENTION OF VCI? Chairs: Masafumi Ihara & Satoshi Hosoki

11:00 - 11:10

Invited talk: WW FINGER: Miia Kivipelto (F), Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden

11:10 - 11:20

Invited talk: Optimising trial design FINESSE: Hugh Markus (M), University of Cambridge, UK

11:20 - 12:30

Invited talk: Treatment Targets in VCI: Atticus Hainsworth (M), St George’s, University of London, UK

11:30 - 11:40

Invited talk: AMCAD study: a multicenter randomized phase II study for CADASIL: Masafumi Ihara (M), National Cerebral and Cardiovascular Center, Osaka, Japan

11:40 - 12:10

Discussion:

12:10 - 12:25

3 selected abstracts for oral presentation (5 mins each)

12:25 - 12:35

Presentation of abstract awards

12:35 - 12:40

Thank you & acknowledgements from the EC Chair

12:40 - 13:00

Local Organizing Committee Chairman’s conclusions: Ingmar Skoog

13:00 - 14:00

Business meetings: General assembly