VasCog 2023

Program
What's on

PRE – CONFERENCE AFTERNOON MASTER CLASSES

September 13th 14:00 – 18:00

Co-Chairs: Anna Marseglia and Hilde van den Brink

Conference room RunAn – Snack and drinks will be delivered at 17.00

14:00 - 15:00: Master class 1: VCI - Diagnosis and neuropathological features

Eric Smith

Raj Kalaria – Download PDF

Julie Schneider

15:00 - 15:15: Discussion

15:15 - 16:15: Master class 2: Biomarkers in VCI

Donna Wilcock – Fluid biomarkers from MarkVCID – Download PDF

Carol Cheung – Retinal biomarkers – Download PDF

Marco Duering – Neuroimaging – Download PDF

16:15 - 16:30: Discussion

16:30 - 17:00: Master class 3: Future challenges in VCI

Geert Jan Biessels – Download PDF

17:00: Early career Investigators (ECI) Mixer and Mingle

MAIN CONFERENCE

Conference room RunAn

08:30 - 08:40

Opening ceremony – Welcome 

  • Ingmar Skoog, Local Host
  • Renée Bengtsson, President of the Regional Council of Västra Götaland
  • Margareta Andersson Broang, Vice Chair of the Municipal Assembly of Gothenbug
  • Secretery General/Chairman – Wellcome on behalf of VasCog

THEME 1: WHATS GOING ON? NEW PERSPECTIVES IN VCI – Chairs: Ingmar Skoog & Anna Marseglia

08:40 - 08:50

Invited talk: Sex differences in VCI-research: from biomarkers to treatment: Lieza Exalto (F), Dept Neurology, UMC Utrecht, the Netherlands

08:50 - 09:00

Invited talk: Resilience pathways in VCI: present challenges and future directions: Prashanti Vemuri (F), Mayo Clinic, USA

09:00 - 09:10

Invited talk: Implementing artificial intelligence methods in VCI: what for? Eric Westman (M), Centre for Alzheimer Research; Department of Neurobiology, Care Sciences, and Society; Karolinska Institutet, Stockholm, Sweden

09:10 - 09:20

Invited talk: Life-time perspective on vascular cognitive ageing / Life-course Epidemiology: Deborah Gustafson (F), State University of New York Downstate Health Sciences University and Stony Brook (SUNY DHSU, SBU), USA

09:20 - 09:30

Invited talk: New perspectives in neuropathology: Elisabet Englund (F), Division of Pathology, Department of Clinical Sciences, University of Lund, Lund, Sweden

09:30 - 09:40

Invited talk: Brain large artery disease contributions to neurodegeneration: Jose Gutierrez (M), Columbia University, New York, USA

09:40 - 10:10

Discussion

10:10 - 10:25

3 selected abstracts for oral presentation (5 mins each)

  • Predicting Incident Dementia in Cerebral Small Vessel Disease: Comparison of Machine Learning and Traditional Statistical Models: Rui Li

  • Exploring the link between biologically defined resilience, brain pathology, and cognitive functioning in old age and the contribution of biological sex: Anna Marseglia

  • Identifying factors affecting resilience in atrophy-based subtypes of vascular cognitive impairment: Vikram Venkatraghavan

10:25 - 10:45

Coffee

THEME 2: BIOMARKERS OF VASCULAR COGNITIVE IMPAIRMENT Chairs: Saima Hilal and Annemieke ter Telgte

10:45 - 10:55

Invited talk: Advanced diffusion MRI markers of cerebral small vessel disease: Anna Dewenter (F), Institute for Stroke and Dementia Research (ISD) Munich, Germany

10:55 - 11:05

Invited talk: Fluid biomarkers in VCI: Henrik Zetterberg (M), University of Gothenburg, Sweden

11:05 - 11:15

Invited talk: Deep learning for detection of Alzheimer’s disease based on retinal images: Carol Cheung (F), Chinese University of Hong Kong

11:15 - 11:25

Invited talk: Cardiac dysfunction, neuroimaging and cognition: Saima Hilal (F), National University of Singapore

11:25 - 12:00

Discussion

12:00 - 12:15

3 selected abstracts for oral presentation (5 mins each)

  • The relative contributions  of aortic and carotid artery stiffness to CeVD and cognition: Caroline Robert

  • Plasma biomarkers of endothelial dysfunction and cognition: an IPD meta-analysis of cross-sectional data from 9,344 individuals from seven Dutch cohorts: Magdelena Beran

  • Neuroimaging Findings in LifeAfter90: A Diverse Cohort of Oldest-Old: Rachel Whitmer

12:15 - 12:20

Announcement of session on international consortia later that day

12:30 - 14:30

Lunch, poster viewing and discussion at posters. Posters grouped by themes. Not more than 6 posters for each discussion group e.g., clinical symptoms, blood pressure, white matter lesions, and brain imaging methods.

13:00 - 13:45

Poster walk 1 (poster discussion group 1-7)

  • Group 1: Poster 1-6
  • Group 2: Poster 19-24
  • Group 3: Poster 37-43
  • Group 4: Poster 50-55
  • Group 5: Poster 67-72
  • Group 6: Poster 84-89
  • Group 7: Poster 101-105

POSTER INFO

13:50 - 14:30

Lunchtime mixer – International consortia to address the global challenge of Vascular Cognitive Disorders. Speakers will give 2-3-minute talks to present their network or organization. The aim is to provide a quick overview of international networks and organizations and have informal discussions.

Chairs: Atticus Hainsworth & Joanna Wardlaw

1) The Vascular Theme in UK DRI (Joanna Wardlaw)

2) Vascular PIA – Alzheimer’s Association – (Fanny Elahi)

3) STROKOG – current status (Jessica Lo)

4) Meta VCI Map (Geert-Jan Biessels)

5) FINESSE – an update (Christopher Chen)

6) CADASIL – (Danit Saks)

7) International Stroke Genetics Consortium (ISGC) – Genetics of VCID (Stephanie Debette)

8) Reaching international consensus – Delphi and other approaches (Perminder Sachdev, Adam Bentvelzen)

9) Dementias platform UK (DPUK) (Atticus Hainsworth)

10) Diffusion-weighted imaging positive lesion consortium (DIAGNOSE) (Annemieke ter Telgte)

11) International consortium on cerebral microinfarcts (Saima Hilal)

12) MarkVCID Diverse (Charlie DeCarli)

13) WW FINGERS (Miia Kivipelto)

14) African Dementia Consortium AfDC) (Rufus Akinyemi)

14:30 - 15:10

One-minute Poster Blitz: Chair: Audrey Low

15:10 - 15:30

Discussion: Chair: Audrey Low

15:30 - 16:30

Debate 1: Is SVD a clearly defined clinical and pathological entity? YES OR No. Chair: Raj Kalaria

Group 1: Arguing for the motion

1) Julie Schneider

2) Sarah Pendlebury

Group 2: Arguing against the motion

3) Donna WilcocK

4) Eric Smith

16:30 - 17:30

Time for VasCog Early Career Investigators meeting with snacks:

– first half: ‘speed dating’ networking

– second half: round table discussion on ECI activities 2024-2025

18:00 - 20:00

Reception: Hosted by the City of Gothenburg and Region Västra Götaland

08:30 - 08:50

2023 updates – Roxana Carare, SOC Chair

08:30 - 08:40

Update on hypertension: Ingmar Skoog (M), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, AGECAP, University of Gothenburg, Sweden

08:40 - 08:50

Update on atrial fibrillation: Lina Rydén (F), Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, AGECAP, University of Gothenburg, Sweden

THEME 3: INFLAMMATION AND OTHER MECHANISMS OF VCI Chairs: Gupreet Hansra & Jae-Sung Lim

08:50 - 09:00

Invited talk: Failure of clearance of fluids from the brain and pathogenesis of CAA: Roxana Carare (F), University of Southampton, UK

09:00 - 09:10

Invited talk: Inflammasome in cognitive impairment and dementia: Yuek Ling Chai (F), National University of Singapore, Singapore

09:10 - 09:20

Invited talk: Molecular pathogenesis of CARASIL:  Osamu Onodera (M), Niigata University, Japan

09:20 - 09:30

Invited talk: Cerebrovascular and inflamm-ageing link to dementia: Axel Montagne (M), University of Edinburgh, UK

09:30 - 09:40

Invited talk: The brain on fire: inflammation and cerebral small vessel disease: Frank-Erik de Leeuw (M), Radboudumc, Nijmegen, the Netherlands

09:40 - 10:10

Discussion:

10:10 - 10:25

3 Selected abstracts for oral presentation (5 mins each)

  • The impact of chronic hypertension on small vessel disease – neuroinflammation beyond white matter hyperintensities: Gemma Sole-Guardia

  • Trajectories of post-stroke cognitive function related to systemic inflammatory biomarkers and metabolites: The Nor-COAST study: Heidi Vihovde Sandvig

  • TREM2-regulated microglial reactivity confers resilience against vascular contributions to white matter injury and cognitive decline: Stefan Szymkowiak

10:25 - 10:55

Coffee

THEME 4: PSYCHIATRIC CONDITIONS AND VCI Chairs: Jiyang Jiang & Geert Jan Biessels

10:55 - 11:05

Invited talk: Occurrence and prognostic value of neuropsychiatric symptoms in patients with Vascular Cognitive Impairment: Geert Jan Biessels (M), UMC Utrecht, the Netherlands

11:05 - 11:15

Invited talk: Neuropsychiatric profiles in stroke patients: A STROKOG collaboration study: Ben Lam (M), University of New South Wales, Sydney, Australia

11:15 - 11:25

Invited talk: Are neuropsychiatric symptoms associated with cerebral small vessel disease presence and progression?  Una Clancy (F), University of Edinburgh, UK

11:25 - 12:15

Discussion:

12:15 - 12:25

2 selected abstracts for oral presentation (5 mins each)

  • Poststroke apathy: Major role of cognitive, depressive and neurological disorders over imaging determinants: Olivier Godefroy

  • Psychological Resilience In the first year of surviving a Stroke among Africans: Akin Ojagbemi

12:25 - 14:30

Lunch, poster viewing and discussion at posters

12:50 - 13:35

Poster walk 2 (poster discussion group 8-14)

  • Group 8: Poster 7-12

  • Group 9: Poster 25-30

  • Group 10: Poster 56-61

  • Group 11: Poster 73-78

  • Group 12: Poster 90-95

  • Group 13: Poster 106-110, 122

  • Group 14: Poster 116-121

13:35 - 14:20

Poster walk 3 (poster discussion group 15-21)

  • Group 15: Poster 13-18

  • Group 16: Poster 31-36

  • Group 17: Poster 44-49

  • Group 18: Poster 62-66

  • Group 19: Poster 79-83

  • Group 20: Poster 96-100

  • Group 21: Poster 111-115

14:30 - 15:10

One-minute Poster Blitz presentations: Discussion: Chair: Satoshi Saito

15:10 - 15:30

Discussion: Chair: Satoshi Saito

15:30 - 16:30

Debate 2: It is time to force the V in ATN classification: Chair: Silke Kern

Group 1: Pro forcing V in ATN:

1) Henrik Zetterberg

2) Fanny Elahi

Group 2: Against forcing V in ATN:

1) Perminder Sachdev

2) Nicholas Ashton

16:30 - 16:45

CCCB presentation: (Wallin, Hainsworth, Paracampo, Kalaria)

16:45 - 17:45

Business meetings: Executive Committee (Chaired by Gustafson)

19:00 - 24:00

Vas-Cog Party: Kajskjulen 8, Packhusplatsen 11, 411 13 Göteborg, Sverige

08:30 - 08:40

Chair: Deborah Gustafson

Invited talk: It’s all in your head: Vascular Dementia and COVID-19: Gregory Bix (M), Tulane School of Medicine, USA

THEME 5: NEW DIAGNOSES AND CLASSIFICATIONS  Chair: Hilde van den Brink & Godefroi Oliver

08:40 - 08:50

Invited talk: The Boston 2.0 criteria: Eric Smith (m), Cognitive Neurosciences, Stroke Program, University of Calgary, Alberta Canada

08:50 - 09:00

Invited talk: STRIVE-2 criteria: Marco Düring, Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany

09:00 - 09:10

Invited talk: Cognitive diagnostic criteria: Perminder Sachdev (M), University of New South Wales, Sydney, Australia

09:10 - 09:20

Invited talk: ARIA-E and ARIA-H: Sandra Black (F), University of Toronto, Canada

09:20 - 10:05

Discussion:

10:05 - 10:15

2 selected abstracts for oral presentation (5 mins each)

  • Prevalence of non-haemorrhagic CAA markers in a memory clinic cohort: Ana Sofia Costa

  • Sex-specific risk of impaired vascular cognitive impairment in elderly patients with diabetes: Elias Thomas

10:15 - 10:50

Coffee

THEME 6: WHATS NEW IN TREATMENT AND PREVENTION OF VCI? Chairs: Masafumi Ihara & Satoshi Hosoki

11:50 - 11:00

Invited talk: World Wide FINGER: Miia Kivipelto (F), Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden

11:00 - 11:10

Invited talk: Optimising trial design FINESSE: Christopher Chen (m), Director, Memory Aging & Cognition Centre at National University Health System, Singapore.

11:10 - 11:20

Invited talk: Treatment Targets in VCI: Atticus Hainsworth (M), St George’s, University of London, UK

11:20 - 11:30

Invited talk: AMCAD study: a multicenter randomized phase II study for CADASIL: Masafumi Ihara (M), National Cerebral and Cardiovascular Center, Osaka, Japan

11:30 - 11:40

Invited talk: LACI-2: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial: Joanna Wardlaw, University of Edinburgh, Scotland.

11:40 - 12:10

Discussion:

12:10 - 12:25

3 selected abstracts for oral presentation (5 mins each)

  • A comparative study of the environmentally sustainable EAT-Lancet diet vs. the Mediterranean diet in relation to cognitive function and brain integrity among older adults: Jessica Samuelsson

  • MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse – results of the MINERVA randomised controlled trial: Robin Brown

  • Incidence and prognostic indicators of dementia in patients with TIA and stroke: the population-based Rotterdam Study: Frank Wolters

12:25 - 12:40

Presentation of abstract awards

12:40 - 12:45

Thank you & acknowledgements from the EC Chair

12:45 - 13:10

Local Organizing Committee Chairman’s conclusions: Ingmar Skoog

Guests: Sandra Black, Charles de Carli, Raj Kalaria

Reflections on what happened since the first VasCog meeting 20 years ago?

13:10 - 14:10

Business meetings: General assembly